Specific sequence determinants of miR-15/107 microRNA gene group targets
نویسندگان
چکیده
منابع مشابه
Specific sequence determinants of miR-15/107 microRNA gene group targets
MicroRNAs (miRNAs) target mRNAs in human cells via complex mechanisms that are still incompletely understood. Using anti-Argonaute (anti-AGO) antibody co-immunoprecipitation, followed by microarray analyses and downstream bioinformatics, 'RIP-Chip' experiments enable direct analyses of miRNA targets. RIP-Chip studies (and parallel assessments of total input mRNA) were performed in cultured H4 c...
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MicroRNAs (miRNAs) are known to repress gene expression in mammalian species by forming Watson-Crick (WC) base-pairing to the 3′ UTR regions of the target mRNA transcripts (Friedman et al. [2009]). The binding primarily occurs at the 2-7 nucleotide (nt) positions from the 5′ end of the miRNA, which is termed as the “seed" and the binding as the “seed match" (Lewis et al. [2003]). MicroRNA regul...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2011
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkr532